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EGCG monomer

source:local time:2013/10/17

EGCG monomer

Molecular formula: C22H18O11 

CAS number:989-51-5

EGCG is the most abundant catechins in tea and is a potent antioxidant that may have therapeutic 

applications in the treatment of many disorders. It is found in green tea but not black tea. During 

black tea production, the catechins are converted to theaflavins and thrarubigins. In a high temperature 

environment, an epimerization change is more likely to occur, the amount lost in a brief exposure is 

insignificant. In fact, even when special conditions were used to create temperatures well above that 

of boiling water, the amount lost increased only slightly.

Additionally, it was found to be a strong topoisomerase inhibiotr, similar to some chemotherapeutic 

anticancer drugs. This property might be responsible for observed anticarcinogenic effects;  however, 

there is also a carcinogenic potential. High intake of polyphenolic compounds during pregnancy is 

suspected to increase risk of neonatal leukemia. Bioflavonoid supplements should not be used by 

pregnant women. EGCG has been possibly implicated in reducing the risk of cancer, and in increasing 

fal-loss. Further studies are underway to investgate such possibilities in human subjects. It is believed 

by some to improve cholesterol levels. However studies have not found such a link. Some evidnece 

suggests that high consuption of tea can reduce the risk of dementia, and the risk of certain cancers.